Venturing into New Frontiers! KeKe MedTech Focuses on Stem Cell Innovations in Dentistry

Stem cells, which have the ability to repair, regenerate and differentiate into various cells of tissues and organs, have become the research focus of regenerative medicine in recent years. The repair and regeneration function of stem cells can be applied to human body. With the emerging and development of tissue engineering and biomaterials, its application becomes increasingly extensive. Dr. Dinghong Chiang, a dentist with many years of clinical experience, as well as the founder and general manager of KeKe MedTech, pointed out that with the advancement of technologies and the relaxation of regulations, the application of immunotherapy would become more and more diverse. In addition to being a new hope for cancer treatment, stem cells could also be applied in articular cartilage repair, aesthetic medicine and other fields. KeKe MedTechg has targeted the latest stem cell applications and applied its research and development to innovative medical materials in dentistry, which also makes the regeneration and repair of teeth and gums full of possibilities in the future. From the perspective of dental professionals, Dr. Dinghong Chiang believes that time is a key factor affecting the effectiveness of dental treatment. He explained with examples that, in the past, tooth implants took four to six months to complete. This is because in the process of tooth implantation, the position for the tooth implantation need to be cut open, and the tooth hole need to be drilled in the alveolar bone for tooth implantation, and then the artificial tooth root and healing cap need to be implanted. It usually takes up to several months for the bone to heal and coat the implant and combine firmly. If not properly cleaned, it may lead to bacterial infection and “peri-implantitis”, and may even lead to tooth implantation failure in serious cases. For patients, the time to wait is too long, and it may also increase their physical and mental burden. In the future, through introducing stem cells combined with dental materials, it is expected to accelerate the wound healing efficiency of patients with dental implants. What’s more, for patients, this can not only reduce the risk of infection, but also reduce the time to wait, bringing a better treatment experience and effectiveness.

Win-win co-operation - new application of stem cells in dentistry

For the reasons given above, based on many years of dental clinical experience, KeKe MedTech cooperated with Taiwan’s leading companies of stem cell research, including BIONET, DrSignal Biotechnology, Gwo Xi Stem Cell, and Maria Von Med-Biotechnology. They jointly research and develop innovative dental materials based on stem cells and conduct cooperation in clinical trials, breaking the limitations of the past periodontal and pulp regenerative repair and regenerative support materials.

In fact, in recent years, continuous bio-3D printing of a variety of materials and cellular biomaterials has become a hot research direction. Dr. Dinghong Chiang pointed out that studies in the Journal of International Clinical Dental Research Organization (January 2010) and the Journal of Periodontics (January 2007) found that the injection of autologous gingival fibroblasts into the gingival papilla with a 30-g needle was proven to have the effect of shortening the papillary interval and promoting the regeneration of gingival hyperplasia. In the future, it may be used in the adjuvant therapy of periodontal diseases or the treatment of gingival recession caused by other reasons.

Dr. Dinghong Chiang said that the medical community is researching materials with all of the above-mentioned properties, and KeKe MedTech is cooperating with TWSE/TPEx listed biotech companies to research and develop innovative medical materials, which mainly includes stem cell exosomes that have the function of repairing cells. Exosomes are the derivative products of cells, and they are also the research focus of emerging biological therapies.

Exosome applications are booming worldwide

The Taiwan Alliance for Extracellular Vesicles pointed out that the research of exosome have become a hot topic in the medical field, and relevant regulations and guidelines have attracted a heated discussion gradually. For example, the Center for Drug Evaluation (CDE) of China published guidelines for vesicles recently, and Japan announced guidelines on exosome earlier this year. In Taiwan, the Regulations Governing the Application of Specific Medical Technique and Medical Device has approved the use of autoimmune cells. In addition, the draft of the Regenerative Medicine Law being promoted in Taiwan has also included exosomal organelles in the scope of application, which is expected to provide assistance to the development of Taiwan’s related industries.